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Liver-directed therapies with efficacy in metabolic dysfunction-associated steatotic liver disease (MASLD), including incretin-based agents, fibroblast growth factor 21 analogs, peroxisome proliferator-activated receptor agonists, and thyroid hormone receptor beta agonists, may benefit selected MetALD patients

The scientists behind these discoveries could be among the 2025 Nobel Prize winners.

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Ferroptosis, a regulated cell death driven by lipid peroxidation, represents a novel pathological mechanism

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Methods This narrative review is based on a comprehensive analysis of the supplied literature set, prioritizing high-level evidence from systematic reviews, meta-analyses, clinical guidelines, and key original studies published between 2021 and 2025