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#### Summary points Interstitial cystitis or painful bladder syndrome is a chronic, often debilitating, condition largely defined by symptoms of urinary urgency and frequency associated with pelvic pain that varies with bladder filling.1 Unlike bladder inflammation caused by bacterial infection, the condition occurs in the absence of urinary tract infection or other obvious pathology

Screening of one such library comprised of these indoles identifies JWU-A021 to be an especially potent stimulator of glucagon-like peptide-1 (GLP-1) secretion in vitro

we hope this guide, written by academics, consultants, GPs and a patient with lived experience will help you to prescribe safely particularly in primary care: don't forget to think about the risks with polypharmacy as people lose weight, the return of fertility, risks and side effects, masked malignant weight loss, the risks of malnutrition in obesity (particularly for those who struggle to afford nutritious food) enquire about what people are actually eating (rather than just about caloric reduction or weight lost): "when did you last eat a green leafy vegetable?", "what did you have for breakfast/lunch/dinner yesterday?", "what are you drinking?" are good enough screeners for most people in short consultations: *dietary quality matters* British Society of Lifestyle Medicine Royal College of General Practitioners Sarah Le Brocq Dr Laurence Dobbie Barbara McGowan Dipesh C