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A collection of Curbside Consultation published in AFP is available at Copyright 2026 by the American Academy of Family Physicians

The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases

Indication: Once-daily oral semaglutide is indicated for adults with obesity (BMI 30 kg/m), or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, as an adjunct to reduced-calorie diet and increased physical activity

KNDy, kisspeptin/neurokinin B/dynorphin neurons

Vehicle-treated Gipr fl/fl and Gipr Syn/ mice showed a 1.5% and 2.6% weight gain, respectively, whereas mGIPR-Ab/P1-treated Gipr fl/fl mice lost 20% of their body weight (Fig