american diabetes association pancreatitis glp-1 receptor agonist history Diabetic Agents, From Metformin to SGLT2 Inhibitors and GLP1 Agonists: JACC Focus Seminar american diabetes association 'history of

Of the remaining 182 articles, 171 were animal studies, and 6 studies had inconsistent methods, so they were excluded

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To improve tolerability, gradual dose escalation proves beneficial

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Physiology and pharmacology of effects of GLP-1-based therapies on gastric, biliary and intestinal motility

Clinical Scenarios of Interest To address further practical considerations, four clinical scenarios are described that are aimed at providing clues for the better management of GI AEs in those patients at higher risk of these complications that are going to undergo GLP-1 RA-based therapy (Table 4)