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The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily

Food intake was weighed daily, with all groups allowed to feed ad libitum

Ann NY Acad Sci 2003

The drugs spurred greater and faster weight loss, in a wider range of people, than any other product in history

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In a 2021 trial in nondiabetics with obesity, semaglutide 2.4mg/weekly induced a 35% reduction in the subjects ad libitum (unrestricted) energy intake after just 20 weeks
