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A retrospective analysis of tens of thousands of patients with type 2 diabetes (including pooled data from three randomized, double-blind trials), published in the journal Alzheimer's & Dementia in 2022, showed that the incidence of dementia was significantly lower in those with diabetes who had used GLP-1 receptor agonists than in controls (HR: 0.47, 95% CI: 0.25-0.86)

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These medications help people lose weight by suppressing appetite and slowing digestion, leading to lower food intake and, subsequently, significant weight reduction

While the degree of change in BMI in published case reports, case series, and RCTs are inconclusive, GLP-1RAs may offer a new approach to HO treatment as the action of GLP-1 on appetite and energy regulation combines hypothalamic signaling and pathways that are independent of hypothalamic signaling