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Fatigue and energy effects Tiredness and fatigue are reported by a significant minority of tirzepatide users, and these effects correlate with drug exposure levels

This dual action in tirzepatide may contribute to a different side effect profile, though the occurrence of headaches is comparable between the two medications

It acts on receptors in the hypothalamus and brainstem to reduce hunger signals and increase satiety

Increasing your dose before your body has acclimated increases the risk of side effects including nausea, vomiting, and GI discomfort

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The dual mechanism produces greater glycemic control and weight loss than GLP-1 agonists alone