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According to research published in Cell Reports Medicine in 2026 by Langer et al., the answer is no

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Nausea, vomiting, diarrhea, constipation, abdominal pain , and bloating show up regularly in trials and real-world use

In these trials, participants achieved a mean weight loss of approximately 15% of body weight over 68 weeks-correlating with a substantial calorie deficit that contributes to initial fatigue

Persistent glucose variability increases oxidative stress and inflammatory signaling

Cardiovascular disease is the main cause of mortality in individuals with MASLD, who face a two- to threefold greater risk of both fatal and non-fatal cardiovascular events than the general population [14]