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As amylin and GLP-1 target different populations of neurons in the DVC 20 , this suggests that combination drug therapies affecting both systems may provide a greater magnitude and sustainable degree of weight loss compared to monotherapies due to a reduced likelihood of tachyphylaxis 21,22,23

Patients and clinicians must remain vigilant in monitoring symptoms and maintaining clear communication about any changes

formal analysis, K.B

In December 2024, Teva secured regulatory approval for a Victoza generic for type 2 diabetes

Studies such as the SUSTAIN and STEP trials have demonstrated their benefits in both glycemic control and weight reduction, positioning GLP-1 agonists as cornerstones in the treatment of metabolic disorders

Clinicians should consider checking serum bicarbonate at baseline and periodically during treatment, particularly in patients with renal impairment, those following a ketogenic diet, or those taking other carbonic anhydrase inhibitors