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In human studies, a meta-analysis with 20 RCTs in patients with type 2 diabetes found vitamin D supplementation significantly improved serum 25(OH)D levels and homeostasis model assessment of insulin resistance [36]

doi: 10.1038/s42255-023-00931-7 55 ZhangQDelessaCTAugustinRBakhtiMColldenGDruckerDJet al

We additionally summarize the evidence by domain and certainty level in a structured Supplementary Table 6, explicitly separating relatively robust short-term metabolic evidence from more exploratory reproductive and periconception safety findings

However, further studies are warranted to determine how chronic treatment with P5 affects PPAR activity and systemic insulin sensitivity in DIO mice

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