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In chronic pain states, TRPV1 channels are upregulated in nociceptive neurons, which lowers stimulation thresholds and increases pain perception, as reported in hyperalgesia or allodynia 21
Practice Point 4.3.2: To minimize gastrointestinal side effects, start with a low dose of GLP-1 RA, and titrate up slowly.
Accessed March 9, 2023
Roux-en-Y gastric bypass in rats increases sucrose taste-related motivated behavior independent of pharmacological GLP-1-receptor modulation
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