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Berberine is a plant alkaloid affecting glucose metabolism at the cellular level, while GLP-1 agonists regulate appetite and insulin secretion through hormone signaling

These results suggest that exendin-4-induced suppression may be mediated by a distinct Gs/cAMP-PKA/IP3/Ca2+/CaM/CaMKII signaling pathway, following the activation of GLP-1Rs.

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