retatrutide triple agonist glp-1 gip glucagon receptors Demonstrated metabolic effects of GIP, and GCG agonism as mono, Retatrutide just had its biggest

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Together, they help optimise GLP-1 activity, reduce cravings, and support healthy, sustainable weight management without the need for synthetic interventions

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Implications for treatment selection As combination products become more common, the distinction between insulin and GLP-1 therapy becomes more important, not less