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Jason Nagata, MD 13, an eating-disorders expert and associate professor of pediatrics, says social pressure to look thin never really went away

"That was the first time I was able to say as an obesity medicine specialist that if I give you this drug, I can likely improve your life and reduce your chance of dying from cardiovascular disease

Research has suggested that exercise is unlikely to result in substantial weight loss unless paired with caloric restriction

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For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses

Glucagon-like peptide-1 receptor agonists improve biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomised controlled trials