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The median HbA1C recorded 12 months after treatment was initiated was used as the after-treatment HbA1C
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In human iPSC-derived dopaminergic neurons from PD patients with SNCA mutations, exendin-4 restored insulin signaling, improved mitochondrial function, and reduced -synuclein aggregation via PI3K/Akt/mTOR activation (26)

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115 Neither of these trials met the primary endpoint, and no improvement in fibrosis was noted

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