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Patients who were diagnosed with diabetes or overweight/obesity were separated

Concurrently, high glucose suppressed the tumor suppressor TIF1, further amplifying Smad-mediated transcription and elevating the expression of pro-oncogenic genes, including the epithelialmesenchymal transition markers N-cadherin and vimentin, thereby collectively fostering CRC progression

Involving the patient in treatment decisions also helps with adherence to therapy, which is a major challenge in T2DM

Food & Drug Administration (FDA-b)

& Sokolowski, C

Time-sensitive dosing : A gap in treatment requires starting at the lowest dose again, increasing the time to reach therapeutic levels