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Steven Heymsfield finds that a GLP-1 therapy combined with bimagrumab, an investigational agent that blocks activin signaling pathways, results in greater weight reduction than either drug alone A recent research study found that a combination of the GLP-1 receptor agonist semaglutide and bimagrumab, an antibody that blocks activin signaling pathways, results in greater weight loss while also preserving lean mass, such as skeletal muscle and connective tissue

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They had a 10% higher risk of osteoarthritis, a 14% higher risk of CKD, a 22% higher risk of OSA, and a 69% higher risk of heart failure

Patients with pre-existing heart conditions, hypertension, or arrhythmias face elevated risks

[DOI] [PubMed] [Google Scholar] 4.Nauck M.A., Quast D.R., Wefers J., Meier JJ

doi: 10.2165/00002018-200225060-00001 26 ShuYDingYHeXLiuYWuPZhangQ