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Consoli A, Formoso G, Baldassarre MPA, et al

Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors

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The European Medicines Agency recently recommended authorising liraglutide for weight loss in children under 12, following publication of a year-long randomised trial in 82 children showing a beneficial reduction in BMI

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The BMJ/MAGIC Group found that Asian, African, or Hispanic ethnicity was a risk factor for cardiovascular and renal outcomes and increased benefits of the medications, although race and ethnicity are social constructs that may not represent a genetic predisposition
