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GLP-1 Agonists (Glucagon-like peptide-1 receptor agonists) have been around for many years

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Clostridium butyricum is a beneficial anaerobic gut bacterium that produces butyrate, a short-chain fatty acid essential for gut lining health and immune balance

Also FDA-approved for obstructive sleep apnea

Although these data show a favorable riskbenefit profile for GLP-1RA, there are differences between individual drugs with respect to their effect on cardiorenal outcomes in the separate trials

The first study (2023) evaluated 7,051 patients undergoing TKA who were prescribed semaglutide preoperatively, comparing them to a matched control group of 34,524 non-users