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Thus, a number of GIPR antagonists are being developed for the treatment of obesity-diabetes [117]

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Semaglutide, a GLP-1 receptor agonist approved in 2021, demonstrated much greater weight loss than previous medications, which stimulated the development of poly-agonists that combine GLP-1 receptor agonism with GIP and glucagon receptor agonism

Competing Interests The authors declare no competing interests

[DOI] [PubMed] [Google Scholar] 17.Ryan D.H., Lingvay I., Deanfield J., Kahn S.E., Barros E., Burguera B., Colhoun H.M., Cercato C., Dicker D., Horn D.B., et al

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