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Accumulation of methylglyoxal (MG) contributes to glucotoxicity and mediates beta cell apoptosis

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Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins

Hot flashes are not a primary listed side effect of Ozempic, though rapid weight loss and metabolic changes may trigger vasomotor symptoms in some patients

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