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148 These drugs act by simultaneously targeting three different agonists GLP-1R, the GIPR, and the GCGR

These hypotheses require further confirmation

Dual GLP-1/GIP agonist tirzepatide for diabetes and obesity: a review of the evidence

Retatrutide Name: Retatrutide Manufacturer: Eli Lilly Current stage: Phase III results expected late 2025/2026 Takeaway: If licensed, it could be more effective for weight loss than other GLP-1s

doi: 10.1136/jnnp.71.1.1

Semaglutide reduced major adverse cardiovascular events in patients with type 2 diabetes at high cardiovascular risk. (Marso, New England Journal of Medicine )
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