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As part of the incretin hormones, GLP-1 has three known mechanisms of action: activating glucose-dependent insulin secretions, thereby reducing plasma glucose, suppressing glucagon secretion, and delaying gastric emptying [3]

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The study examined pregnancy outcomes among women who were exposed to GLP-1 medications early in pregnancy, often before realizing they were pregnant

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Additional strategies under investigation aim to develop small-molecule GLP-1R modulators, sustained-release depot formulations, and combination regimens that pair GLP-1R agonists with complementary agents to maximise metabolic and organ-protective benefits

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Pories W, Card J, Flickinger E, Meelheim H, Swanson M