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However, some patients need additional support to stay comfortable during the adjustment period

GLP1 also decreases both the release and breakdown of stored carbohydrates as well as the synthesis of new glucose by inhibiting the production of glucagon which is a hormone responsible for increasing glucose levels in the body

Originally approved as a once-weekly injectable for type 2 diabetes, Mounjaro has gained attention for producing large, clinically significant weight loss

Patients may be more stringently screened, particularly for thyroid nodules/cancer in patients receiving GLP-1 receptor agonists

The pooled analysis from SURMOUNT-1, SURMOUNT-2, and SURMOUNT-3 trials included 4,056 adults with obesity who were assessed using validated measures including the Patient Health Questionnaire-9 (PHQ-9) for depressive symptoms and the Columbia-Suicide Severity Rating Scale (C-SSRS) for suicidal ideation and behavior