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Description
December 2020: The MDLs were closed
Building upon the established effects of GLP-1 receptor agonists, dual GCG/GLP-1 receptor agonists simultaneously improve the two core pathogenic mechanisms of diabetes - insufficient insulin secretion and insulin resistance, thus, delivering comprehensive benefits beyond glycemic control, including weight loss, and hepato-cardio-renal metabolic improvements
Highlights of prescribing information: Cinryze
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This corresponds to a 1.5% absolute risk reduction, meaning that for every 67 patients treated, one cardiovascular event was prevented
Obesity (BMI 30) has been shown to increase the risk of all-cause mortality by up to 108%
