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Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: a randomized, double-blind, placebo-controlled trial

2022;146(5):e1843

One study conducted in human subjects showed that CAT expression differs according to the stage of MASLD, with expression generally increased in the early stage of MASLD and decreased in the terminal stage of MASH (Shin et al

The resulting DNA hypomethylation leads to changes in gene expression that underlie elements of the pathophysiology of ALD ( In contrast, histone methylation does not globally increase or decrease based on the methylation index

151 SauterM.MoffattB.SaechaoM

The relationship between dose and response follows a curve that plateaus, not a straight line that keeps climbing
