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Both SGLT2-i and valsartan/sacubitril reduce Na+ reabsorption in the proximal tubule and therefore stimulate TGF

This means researchers can use these compounds only for in-vitro laboratory testing and controlled experimentation

Mean Difference, Standardized Mean Difference (SMD), and Their Use in Meta-Analysis: As Simple as It Gets

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Mnzberg H, Laque A, Yu S, Rezai-Zadeh K, Berthoud HR