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A 2025 Bayesian network meta-analysis of 48 RCTs covering 27,729 participants compared GI adverse events across the major GLP-1 RAs.[1] Tirzepatide showed the highest risk of nausea and diarrhea among the agents studied

This is an active area of research and reasonable clinicians will differ on specific recommendations

So lets see what we can all learn from this study, to understand how we can better use ketogenic interventions for metabolic and psychiatric care

With proper guidance, GLP-1 medications can be safely used across all CKD stages, including dialysis, offering a tailored solution for diabetes and kidney health management

Noninvasive biomarkers in pediatric nonalcoholic fatty liver disease

In addition, rare post-marketing reports of exenatide, liraglutide, and lixisenatide have been described for pruritus, urticaria, and angioneurotic edema