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Our phentermine vs semaglutide comparison helps clarify when each medication is more appropriate and whether combining them makes sense for your situation

For older adults or those with coronary artery disease, lower starting doses with gradual titration are recommended

Monthly monitoring at stable dose: Once you reach your target dose and heart rate has stabilized (typically after 2 to 3 weeks at the same dose), weekly monitoring can shift to monthly spot checks

The 11.2% discontinuation rate at the highest dose means nearly 89% of participants tolerated treatment successfully through 48 weeks
