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Description
Glucagon-like peptide-1 receptor agonist (GLP-1RAs) and more recently Twin-Cretins (GLP+GIP) are frequently used for patients with diabetes and associated obesity

Mechanistically, these effects are linked to GLP-1 RA-mediated suppression of inflammatory pathways, modulation of skeletal muscle metabolism, and preservation of mitochondrial function, thereby influencing insulin resistance

This article examines clinical safety, muscle preservation concerns, genetic predispositions to medication response, and how providers guide informed decision-making

Injectable weight loss drugs have transformed the treatment of overweight and obesity

Questions, Comments

Semaglutide can lower blood pressure through weight loss and direct cardiovascular effects, but individual responses vary significantly
