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Pre-existing gastrointestinal disorders, particularly functional dyspepsia or irritable bowel syndrome, appear to predispose patients to more pronounced GI symptoms

In addition to areas such as the pancreas, GLP-1 receptors are also located in the brain such as the hypothalamus, nucleus accumbens, hippocampus, and amygdala and GLP-1 RAs also interact with serotonin, dopamine, and glutamate neurotransmitter systems

Impact of baseline glycated haemoglobin, diabetes duration and body mass index on clinical outcomes in the LixiLan-O trial testing a titratable fixed-ratio combination of insulin glargine/lixisenatide (iGlarLixi) vs insulin glargine and lixisenatide monocomponents

What they notice instead is how they feel day to day

GLP-1 agonists are changing obesity care GLP-1 agonists are now going beyond diabetes care

As targets for hormones like GLP-1, GPCRs are central to many obesity therapies
