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Stress and poor sleep quality can also interfere with weight loss hormones like cortisol and ghrelin, counteracting semaglutide's benefits

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Rapid weight loss often includes muscle mass reduction , putting new strain on your joints

The risk is particularly high if alcohol is consumed on an empty stomach or in large quantities

As of July 31, 2025, the FDA has received: Some of these reports involve serious reactions such as nausea, vomiting, abdominal pain, constipation, and dosing errors, especially when patients or providers miscalculate injections or exceed FDA-approved dosing schedules

6 It also slows down digestion, so food stays in your stomach longer