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Effects on Overall eGFR Change (STEP 13) To characterize the effect of semaglutide on kidney function, we pooled the data from the STEP 13 clinical trials, involving 3,379 participants with overweight or obesity with or without type 2 diabetes (data for the semaglutide 1.0 mg treatment arm from STEP 2 were not included in this analysis, but are included for baseline data)

In conclusion, our systematic review and meta-analysis provides evidence of strong potential from GLP-1 RA or GIP/GLP-1 RA treatment in reducing MACE, all-cause and cardiovascular mortality in the T2DM population

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Comparing reflux risk across GLP-1 medications If reflux becomes unmanageable on semaglutide, understanding how it compares to alternatives helps inform discussions with your prescriber about switching options

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