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Nineteen aberrant enrichments KEGG pathways were displayed between DSS-GLP-1 and NT groups, including the microbial genes related to carbohydrate metabolism, nucleotide metabolism, lipid metabolism, metabolism of cofactors and vitamins, and amino acid metabolism

Lincoff et al., NEJM, 2023 (SELECT Trial) Targets a Key Pillar of Aging Semaglutide powerfully addresses metabolic dysfunction, one of the primary 'Hallmarks of Aging', helping to delay the onset of age-related diseases

About a quarter (27%) of GLP-1 users report having insurance but paying the whole cost of the medication themselves

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The potency of semaglutide was first confirmed in 2021 in The New England Journal of Medicine resulting in 14.9% weight loss compared to 2.4% placebo in 1961 subjects over 68 weeks

This modulation occurs through the upregulation of AMPK via cyclic adenosine monophosphate (cAMP) accumulation, potentially impacting infection risk [17]