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& Tiwari, V

Mean weight loss of 20.9% at 72 weeks on 15 mg tirzepatide remains the largest mean weight reduction recorded in any Phase III randomized controlled trial of a pharmacological agent, as of mid-2025

GLP-1 stimulation of adipose tissue monocytes increases IL-6 signaling in adipocytes, leading to increased UCP-1 expression and glucose metabolism [112]

Monitoring for side effects Be vigilant in monitoring for any potential side effects

[DOI] [PubMed] [Google Scholar] 190.Eslami M., Yousefi B., Kokhaei P., Hemati M., Nejad Z.R., Arabkari V., Namdar A

Patients should follow the prescribing information and the directions provided by their medical team
