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In rare cases, GLP-1 agonists may cause serious side effects, including allergic reactions, pancreatitis, gallbladder disease, and kidney disease.[ref][ref] Obviously, talk with your doctor about the risks vs

One common suggestion is overnight blood sugar fluctuation

However, semaglutide has a longer clinical track record, potentially lower side-effect severity for some users, and may be the optimal choice for those with certain genetic profiles or medical histories

Long term data is still needed to understand cardiovascular and kidney outcomes to ensure safe prescribing

By Lana Pine | Published on July 6, 2026 Fact checked by: Afton Woodward 4 min read GLP-1 receptor agonists like semaglutide and tirzepatide have helped millions of people lose significant weight and better manage blood sugar
