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Bupropion for weight loss: an investigation of efficacy and tolerability in overweight and obese women, Obesity Research (2001) Bupropion SR enhances weight loss: a 48-week double-blind, placebo-controlled trial, Obesity Research (2012) Long-term weight change after initiating second-generation antidepressants, Journal of Clinical Medicine (2016) The effects of bupropion alone and combined with naltrexone on weight loss: a systematic review and meta-regression analysis of randomized controlled trials, Diabetology and Metabolic Syndrome (2024) A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II), Obesity (2013) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

GLP-1 receptor agonists can be a game changer for weight loss

The STEP trials for semaglutide showed average weight loss of 12-15% of body weight over 68 weeks in individuals with obesity

At the time, the notion that one molecule could have two separate effects was provocative, as was the thought of having a novel injectable medicine for these conditions