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Description
In animal studies, administration of dexamethasone caused a reduction of GLP-1 secretion from the intestinal L cells [80] and also decreased the circulating levels of this peptide, which led to glucose intolerance and peripheral insulin resistance in rats [81]
Microcrystalline cellulose, hypromellose (vegetarian capsule), silica
On experimental days (weekdays, Mondays to Fridays), daily food allowance was only offered during the food intake sessions (see section Two-session operant food intake paradigm below)
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Cloning of rat and human pancreatic GLP-1R cDNA documented that ligand-induced activation of a single unique GLP-1R increases intracellular levels of cAMP and also that GLP-1, but not glucagon, GIP, VIP, or secretin, activates GLP-1R [[360], [361], [362], [363], [364]]
Kristian Brock, Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, B15 2TT, UK
