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Our studies indicated that DAF-16::GFP relocated to the nucleus following daf-2 RNAi treatment, indicative of ectopic activation of DAF-16 (Supplementary Fig

More recently, this E3 ubiquitin ligase Parkin is shown to negatively regulate NLRP3 in dopamine neurons via ubiquitinating NLRP3 for proteasomal degradation and reducing mitochondrial-derived ROS production (Panicker et al., 2022)

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