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Wean J, Kowalsky AH, Laker R, et al
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GLP-1R is concentrated in POMC/CART neurons of the arcuate nucleus, while GIPR is expressed on different neuronal subsets
They had a baseline glycated hemoglobin (HbA1c) level between 7.5% and 10.5% (58-91 mmol/mol), a body-mass index of 25 kg/m2 or greater, and established cardiovascular disease or a high risk of cardiovascular events
