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New studies from 23andMe suggest genetic variation may modestly influence GLP-1 weight-loss response and side effects

From the phase 3 trials at the 9 mg and 12 mg doses: Nausea: 38.1% (9 mg) to 43.2% (12 mg) versus 10.7% with placebo Diarrhea: 34.7% (9 mg) to 33.1% (12 mg) versus 13.4% with placebo Constipation: 21.8% (9 mg) to 25.0% (12 mg) versus 8.7% with placebo Vomiting: 20.4% (9 mg) to 20.9% (12 mg) Compare those numbers to Mounjaro and the difference is clear

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Makes You Feel Full : GLP-1 helps promote feelings of fullness, which can help you eat less

At this stage, it is more accurate to describe these psychological and QoL improvements as concomitant effects of metabolic and symptomatic relief rather than independent psychopharmacological actions

doi: 10.1038/ijo.2008.148 [DOI] [PubMed] [Google Scholar] 60.Szalowska E, Meijer K, Kloosterhuis N, Razaee F, Priebe M, Vonk RJ