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Contrave costs $444.58 versus Ozempics $329.95

Hence, the effects of GLP-1 RA on the central nervous system may contribute to the induction of weight loss but not necessarily to its maintenance

Semaglutide has the longer real-world track record because it has been in clinical use for diabetes management since 2017, while tirzepatide is newer but has a robust clinical trial dataset behind it

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In the longer term, you could combine a GLP-1 with medication preventing muscle loss, or even more fundamentally, design the weight loss medications to be directed fully to adipose tissue while minimizing muscle loss