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When appetite control gets better, your body focuses less on storing glucose and more on burning stored fat to get energy

Do not use tirzepatide if you or a family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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This genetic context can support conversations with your provider about whether slower titration or alternative dosing strategies might reduce GI discomfort

Talk with your healthcare provider before starting strenuous exercise (such as running, jogging, or lifting weights)

When insulin levels remain high, the body's hormonal environment continues to favor fat storage over fat burning regardless of how little you eat