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The effect is most pronounced during dose escalation

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In hypertension models, GLP-1 RAs exert beneficial effects through multiple mechanisms including vascular vasodilation, diuresis, decreased sympathetic activity in the central nervous system, and reduced blood pressure variability (BPV) [15]

This is because body composition can improve even when total weight moves slowly

Pharmaceutical Research (1999) 7

Practical Implications: For magnesium supplements, this could mean that it might take longer for them to become fully absorbed or for their effects to be perceived
