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Critically, subsequent metagenomic analysis revealed that LEO (60 mg/kg) effectively reversed diabetes-associated dysbiosis, evidenced by a marked increase in -diversity (Shannon index), elevated relative abundance of Firmicutes, and specific enrichment of butyrate-producing genera such as Alistipes (Figures 3BE)

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Source: Lancet Brain imaging (DaTScan) also suggested a trend towards reduced rate of decline in the exenatide-treated group when compared with the placebo group