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From a customer perspective, they should not be interpreted as instructions, safety advice or personal-use guidance

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Those who took GLP-1s for less than 18 months before discontinuing saw no significant risk reduction compared to the group on sulfonylureas at the end of the trial

GLP-3 is the name used here to describe a synthetic research peptide known in scientific literature as retatrutide

The treatment policy estimand evaluated the treatment effect among all participants, regardless of treatment discontinuation or rescue intervention, while the trial product estimand addressed the average treatment effect in all participants assuming adherence to the treatment protocol