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One other downside that I think you didn't point to specifically, but you meant in saying there's some unknown downside to this, there are some early studies that are showing that you lose more lean muscle mass when you're on a GLP-1 than if you were just doing diet and exercise

Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes -cell subpopulations with dynamic transcriptome profiles

doi: 10.1016/j.brainres.2008.12.026 [DOI] [PMC free article] [PubMed] [Google Scholar] 108.Han H, Wu LM, Han MX, Yang WM, Wang YX, Fang ZH

These expanded uses position GLP-1s as multi-system therapies, not just treatments for diabetes or high obesity rates
