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doi: 10.1002/dmrr.v29.1 32 SchauerIESnell-BergeonJKBergmanBCMaahsDMKretowskiAEckelRHet al

Alterations in resting metabolic markers and substrate use measured via indirect calorimetry have been observed in controlled trials, consistent with a synergistic effect on metabolism and fat partitioning

The trial to examine the efficacy of the drug for obesity started with the injection of 0.25mg of semaglutide weekly for the first 4 weeks, with the dose increased every 4 weeks to reach the maintenance dose of 2.4mg weekly by week 16 (lower maintenance doses were permitted if participants had unacceptable side effects with the 2.4mg dose)

The intraretinal fluid extended slightly into the macula with the fluid margin 2.4 mm from fovea centralis corresponding to within the ETDRS grid (scan including ETDRS grid was not obtained)

Thus, tirzepatide appears to outperform semaglutide at doses that comparably engage the GLP-1R

Philadelphia: Saunders