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It works by irreversibly blocking the hydrogen-potassium ATPase enzyme system (the proton pump) in gastric parietal cells, thereby decreasing acid secretion into the stomach
A meta-analysis shows that while using exercise alone leads to weight loss, combination with dieting showed a greater weight loss

Patients with certain genotypes may need lower starting doses to avoid early exhaustion
This is one of the most frequent and underappreciated contributors to a stalling deficit
It is also indicated to reduce the risk of stroke, heart attack, and death in patients with diabetes and cardiovascular disease, says Katherine H
