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In conclusion, compared with existing observational studies, MR with SMR simulates the process of random assignment of parental alleles to offspring, and thus can effectively reduce confounding-induced bias and enhance causal inferences [7]

For individuals managing weight or metabolic health while breastfeeding, this decision requires balancing treatment goals with infant safety

Randomized data and follow-up reports indicate decreases in hepatic fat surrogates and waist-based measures, suggesting improvement in the metabolic milieu entering pregnancy

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[DOI] [PubMed] [Google Scholar] 69.Wilding J.P.H., Batterham R.L., Davies M., Van Gaal L.F., Kandler K., Konakli K., Lingvay I., McGowan B.M., Oral T.K., Rosenstock J., Wadden T.A., Wharton S., Yokote K., Kushner R.F., STEP 1 Study Group Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension